个人简介
姓 名：唐汝培
邮 箱：tangrp99@iccas.ac.cn; tangrp@ahu.edu.cn
职 称：教授
联系电话：
地 址：安徽省合肥市经开区九龙路111号
安徽大学新校区笃行北楼B406、407室
邮政编码: 230601
个人简介：
　　唐汝培（博士，教授，博士生导师），男，生于1977年8月。1999年6月本科毕业于武汉大学化学与环境科学学院，获理学学士学位；1999年9月至2002年6月在武汉大学资源与环境科学学院学习获理学硕士学位，研究方向为基于天然聚多糖的环境友好材料；2002年9月至2005年6月在中国科学院化学研究所学习并获理学博士学位，研究方向为新型聚合物电致发光材料的设计、合成及性能研究。2005年8月至2006年5月在武汉理工大学化学与工程学院任讲师、副教授。2006年6月至2009年11月在美国明尼苏达大学生物医学工程系从事生物材料及药物传递等方面的博士后研究工作。2009年12月至2013年4月在江南大学药学院工作，任教授，硕士研究生导师，主要从事生物材料与缓释给药技术研究；2013年5月至今，安徽大学生命科学学院工作，任教授，博士生导师。2010年12月入选江苏省高校“青蓝工程”优秀青年骨干教师培养对象，2011年12月入选教育部“新世纪优秀人才”支持计划。
　　自2009年以来，从事具有良好生物相容性、特异靶向性及药物缓控释放特性的多功能生物材料的设计、制备与性能研究，主要研究方向包括生物可降解大分子材料的分子设计和可控合成、靶向药物控释制剂及纳米药物制剂等，所开展的研究课题基本上处于生物大分子、天然产物及药学等交叉领域的前沿，已在Biomaterials、Journal of Controlled Release、ACS Applied Materials & Interfaces、Acta Biomaterialia、Biomacromolecules、Polymer Chemistry、Macromolecular Bioscience等SCI期刊发表六十余篇研究论文。目前主要从事环境响应型生物材料的应用基础研究，在生物材料的生物相容性和生物（药学）功能性方面开展了较为系统的研究，形成了基于酸敏感原酸酯键构建具有环境响应性新型生物材料的研究特色；研究发现基于原酸酯构建的生物材料具有环境刺激响应性，能对外界环境pH及温度的细微变化做出（超）灵敏反应；其作为药物及基因传递载体，可根据需要赋予载体环境刺激响应性，发挥智能载体的协调性，促进药物和治疗基因从载体材料中释放，有助于药物与目标靶点的相互作用，增强基因表达的水平以及实现缓释给药。
研究项目：
◇产学研合作方式委托研发类课题：新型淀粉基药用辅料产品研发，项目负责人。
◇产学研合作方式委托研发类课题：安徽大学思颖柏霖生物医学材料工程研究中心，项目负责人。
◇产学研合作方式委托研发类课题：新型羟丙甲纤维素衍生物药用辅料产品研发，项目负责人。
◇国家自然科学基金：具有胞内缓释功能的新型pH敏感聚合物基因载体的合成与性能研究，项目负责人。
◇教育部新世纪优秀人才支持计划：药物合成与缓释给药技术研究，项目负责人。
◇国家自然科学基金：具有二级核-壳结构的新型酸敏感聚合物纳米胶束的设计、制备及性能研究，项目负责人。
◇教育部第43批留学回国人员科研启动基金；新型pH敏感聚合物纳米胶束的设计、制备及性能研究，项目负责人。
◇安徽省自然科学基金：新型pH敏感聚合物基因载体的设计、合成及性能研究，项目负责人。
近期发表文章：
　　*表示通讯联系人
2018年 ~ 至今
Jun Wang, Yu Lu, Shuting Li, Xin Wang, Yan Huang, Rupei Tang*, pH-sensitive amphiphilic triblock copolymers containing ortho ester mainchains as efficient drug delivery platforms, Materials Science & Engineering C 2019, 94, 169–178.
Le He, Min Sun, Xu Cheng, Yong Xu, Xiaodong Lv, Xin Wang*, Rupei Tang*, pH/redox dual-sensitive platinum (IV)-based micelles with greatly enhanced antitumor effect for combination chemotherapy, Journal of Colloid and Interface Science 2019, 541, 30–41.
Min Sun, Le He, Xin Wang, Rupei Tang*, Acid-breakable TPGS-functionalized and diallyl disulfide-crosslinked nanogels for enhanced inhibition of MCF-7/ADR solid tumours, Journal of Materials Chemistry B 2019, 7, 240–250.
Jiejie Qin, Yan Huang, Guoqing Yan, Jun Wang, Liefeng Hu, Panpan Zhang, Rupei Tang*, Phenylboronic acid-functionalized ultra-pH-sensitive micelles for enhanced tumor penetration and inhibition in vitro, Journal of Materials Science 2019, 54, 5695–5711.
Shuting Li, Liefeng Hu, Dapeng Li, Xin Wang, Panpan Zhang, Jun Wang, Guoqing Yan, Rupei Tang*, Carboxymethyl chitosan-based nanogels via acid-labile ortho ester linkages mediated enhanced drug delivery, International Journal of Biological Macromolecules 2019, 129, 477–487.
Min Sun, Xin Wang, Xu Cheng, Le He, Guoqing Yan, Rupei Tang*, TPGS-functionalized and ortho ester-crosslinked dextran nanogels for enhanced cytotoxicity on multidrug resistant tumor cells, Carbohydrate Polymers 2018, 198, 142–154.
Xu Cheng, Jiejie Qin, Xin Wang, Qian Zha, Weijing Yao, Shengxiang Fu, Rupei Tang*, Acid-degradable lactobionic acid-modified soy protein nanogels crosslinked by ortho ester linkage for efficient antitumor in vivo, European Journal of Pharmaceutics and Biopharmaceutics 2018, 128, 247–258.
Xin Wang, Jie Luo, Le He, Xu Cheng, Guoqing Yan, Jun Wang, Rupei Tang*, Hybrid pH-sensitive nanogels surface-functionalized with collagenase for enhanced tumor penetration, Journal of Colloid and Interface Science 2018, 525, 269–281.
Xin Wang, Le He, Bing Wei, Guoqing Yan, JunWang, Rupei Tang*, Bromelain-immobilized and lactobionic acid-modified chitosan nanoparticles for enhanced drug penetration in tumor tissues, International Journal of Biological Macromolecules 2018, 115, 129–142.
Guanqing Yang, Shengxiang Fu, Xin Wang , Jun Wang, Rupei Tang*, pH-triggered poly(ethylene glycol) nanogels prepared through orthoester linkages as potential drug carriers, International Journal of Polymeric Materials and Polymeric Biomaterials 2018, 67, 1059–1068.
Weijing Yao, Xu Cheng, Shengxiang Fu, Guoqing Yan, Xin Wang, Rupei Tang*, Low molecular weight polyethyleniminegrafted soybean protein gene carriers with low cytotoxicity and greatly improved transfection in vitro, Journal of Biomaterials Applications 2018, 32, 957–966.
Yan Huang, Jiejie Qin, Jun Wang, Guoqing Yan, Xin Wang, Rupei Tang*, Dual-stimuli-sensitive poly(ortho ester disulfide urethanes)-based nanospheres with rapid intracellular drug release for enhanced chemotherapy, Science China Chemistry 2018, 61, 1447–1.
2017年
Guoqing Yan, Jun Wang, Liefeng Hu, Xin Wang, Guanqing Yang, Shengxiang Fu, Xu Cheng, Panpan Zhang, Rupei Tang*，Stepwise targeted drug delivery to liver cancer cells for enhanced therapeutic efficacy by galactose-grafted, ultra-pH-sensitive micelles, Acta Biomaterialia 2017, 51, 363–373.
Guanqing Yang, Xin Wang, Shengxiang Fu, Rupei Tang*, Jun Wang, pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy, Acta Biomaterialia 2017, 60, 232–243.
Guoqing Yan, Jun Wang, Panpan Zhang, Liefeng Hu, Xin Wang, Guanqing Yang, Shengxiang Fu, Xu Cheng, Rupei Tang*, Tunable dynamic fluorinated poly(ortho ester)-based drug carriers for greatly enhanced chemotherapeutic efficacy, Polymer Chemistry 2017, 8, 2063–2073.
Liefeng Hu, Panpan Zhang, Xin Wang, Xu Cheng, Jiejie Qin, Rupei Tang*, pH-sensitive carboxymethyl chitosan hydrogels via acid-labile ortho ester linkage for potential biomedical applications, Carbohydrate Polymers 2017, 178, 166–179.
Xin Wang, Bing Wei, Xu Cheng, Jun Wang, Rupei Tang*, 3-Carboxyphenylboronic acid-modified carboxymethyl chitosan nanoparticles for improved tumor targeting and inhibitory, European Journal of Pharmaceutics and Biopharmaceutics 2017, 113, 168–177.
Shengxiang Fu, Guanqing Yang, Jun Wang, Xin Wang, Xu Cheng, Qian Zha, Rupei Tang*, pH-sensitive poly(ortho ester urethanes) copolymers with controlled degradation kinetic: Synthesis, characterization, and in vitro evaluation as drug carriers, European Polymer Journal 2017, 95, 275–288.
Xin Wang, Di Zhang, Jun Wang, Rupei Tang*, Bing Wei, Qiong Jiang, Succinyl pullulan-crosslinked carboxymethyl chitosan sponges for potential wound dressing, International Journal of Polymeric Materials and Polymeric Biomaterials 2017, 66, 61–70.
Zhipeng Cao, Xin Wang, Xu Cheng, Jun Wang, Rupei Tang*, In vitro and in vivo anti-tumor study of folic acid-conjugated carboxymethyl chitosan and phenylboronic acid-based nanoparticles for in vitro and in vivo anti-tumor study, International Journal of Polymeric Materials and Polymeric Biomaterials 2017, 66, 495–506.
Weijing Yao, Qian Zha, Xu Cheng, Xin Wang, Jun Wang, Rupei Tang*, Folic acid-conjugated soybean protein-based nanoparticles mediate efficient anti-tumor ability in vitro, Journal of Biomaterials Applications 2017, 31, 832–843.
Bing Wei, Le He, Xin Wang, Guo Qing Yan, Jun Wang, Rupei Tang, Bromelain-decorated hybrid nanoparticles based on lactobionic acid-conjugated chitosan for in vitro anti-tumor study, Journal of Biomaterials Applications 2017, 32, 206–218.
Guanqing Yang, Shengxiang Fu, Weijing Yao, Xin Wang, Qian Zha, Rupei Tang*, Hyaluronic acid nanogels prepared via ortho ester linkages show pH-triggered behavior, enhanced penetration and antitumor efficacy in 3-D tumor spheroids, Journal of Colloid and Interface Science 2017, 504, 25–38.
Jun Wang, Xin Wang, Guoqing Yan, Shengxiang Fu, Rupei Tang*, pH-sensitive nanogels with ortho ester linkages prepared via thiol-ene click chemistry for efficient intracellular drug release, Journal of Colloid and Interface Science 2017, 508, 282–290.
Guoqing Yan, Jun Wang, Jiejie Qin, Liefeng Hu, Panpan Zhang, Xin Wang, Rupei Tang*, Well-defined poly(ortho ester amides) for potential drug carriers: probing the effect of extra- and intracellular drug release on chemotherapeutic efficacy, Macromolecular Bioscience 2017, 17, **.
Qian Zha, Xin Wang, Xu Cheng, Shengxiang Fu, Guanqing Yang, Weijing Yao, Rupei Tang*, Acid–degradable carboxymethyl chitosan nanogels via an ortho ester linkage mediated improved penetration and growth inhibition of 3-D tumor spheroids in vitro, Materials Science and Engineering C 2017, 78, 246–257.
Xu Cheng, XinWang, Zhipeng Cao,Weijing Yao, JunWang, Rupei Tang*, Folic acid-modified soy protein nanoparticles for enhanced targeting and inhibitory, Materials Science and Engineering C 2017, 71, 298–307.
Shengxiang Fu, Guanqing Yang, Jun Wang, Xin Wang, Xu Cheng, Rupei Tang*, Acid–degradable poly(ortho ester urethanes) copolymers for potential drug carriers: Preparation, characterization, in vitro and in vivo evaluation, Polymer 2017, 114, 1–14.
Guoqing Yan, Qian Zha, Jun Wang, Xin Wang, Xu Cheng, Weijing Yao, Rupei Tang*, Dynamic, ultra-pH-sensitive graft copolymer micelles mediated rapid, complete destruction of 3-D tumor spheroids in vitro, Polymer 2017, 111, 192–203.
Rui Wang, Jiumu Cheng, Guoqing Yan, Chun Wang*, Xin Wang, Jun Wang, Rupei Tang*, Rational design of acid-labile branched polycation with superior gene transfection capacity, Polymer 2017, 123, 1–9.
2016年
Xin Wang, Bing Wei, Xu Cheng, Jun Wang, Rupei Tang*, Phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetrating, Nanotechnology 2016, 27, 385101.
Min Yu, Lei Zhang, Jun Wang, Rupei Tang*, Guoqing Yan, Zhipeng Cao, Xin Wang, Acid-labile poly(ortho ester amino alcohols) by ring-opening polymerization for controlled DNA release and improved serum tolerance, Polymer 2016, 96, 146–155.
Lei Zhang, Min Yu, Jun Wang, Rupei Tang*, Guoqing Yan, Weijing Yao, Xin Wang, Low molecular weight PEI-based vectors via acid-labile ortho ester linkage for improved gene delivery, Macromolecular Bioscience 2016, 16, 1175–1187.
Qiong Jiang, Wei zhou, Jun Wang, Rupei Tang*, Di Zhang, Xin Wang, Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing, International Journal of Biological Macromolecules 2016, 91, 85–91.
Xin Wang, Xiaojing Zhou, Jun Wang, Zhipeng Cao, Lei Zhang, Rupei Tang*, Acid-labile copolymer micelles cross-linked by a twin ortho ester cross-linking agent: synthesis, characterization, and evaluation, Macromolecular Chemistry and Physics 2016, 217, 2182–2190.
2012–2015年
Bing Wei, Yangyang Tao, Xin Wang, Rupei Tang*, Jun Wang, Rui Wang, LiyingQiu, Surface-eroding poly(ortho ester amides) for highly efficient oral chemotherapy, ACS Applied Materials & Interfaces 2015, 7, 10436–10445.
Di Zhang, Wei zhou, Bing Wei, Xin Wang, Rupei Tang*, JieminNie, Jun Wang, Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing, Carbohydrate Polymers 2015, 125, 189–199.
Xiaojing Zhou, Shi Luo, Rupei Tang*, Rui Wang, Jun Wang, Diblock copolymers of polyethylene glycol and a polymethacrylamide with side-chains containing twin ortho ester rings: synthesis, characterization, and evaluation as potential pH-responsive micelles, Macromolecular Bioscience 2015, 15, 385–394 .
Junping Lai, Zhangyan Xu, Rupei Tang*, Weihang Ji, Rui Wang, Jun Wang, Chun Wang*, PEGylated block copolymers containing tertiary amine side-chains cleavable via acid-labile ortho ester linkages for pH-triggered release of DNA, Polymer 2014, 55, 2761–2771.
Zhangyan Xu, Junping Lai, Rupei Tang*, Weihang Ji, Rui Wang, Jun Wang, Chun Wang*, Synthesis and characterization of homopolymers bearing acid-cleavable cationic side-chains for pH-modulated release of DNA, Macromolecular Bioscience 2014, 14, 1015–1024.
Shi Luo, Yangyang Tao, Rupei Tang*, Rui Wang, Weihang Ji, Chun Wang*, Youliang Zhao, Amphiphilic block copolymers bearing six-membered ortho ester ring in side chains as potential drug carriers: synthesis, characterization, and in vivo toxicity evaluation, Journal of Biomaterials Science, Polymer Edition 2014, 25, 965–984.
Qiang Cheng, Yuanyu Huang*, Hua Zheng, Tuo Wei, Shuquan Zheng, ShuaidongHuo, Xiaoxia Wang, Quan Du, Xiaoning Zhang, Hong-Yan Zhang, Xingjie Liang, Chun Wang, Rupei Tang*, Zicai Liang*,The effect of guanidinylation of PEGylated poly(2-aminoethyl methacrylate) on the systemic delivery of siRNA, Biomaterials 2013, 34, 3120–3131.
Rupei Tang*,Wenqing Zhang, Deping Qian, Hua Zheng, Zhan'ao Tan*,Synthesis, characterization, and electroluminescent properties of pyridinylenevinylene modified phenylenevinylene copolymers, Journal of Electronic Materials 2012, 41, 2447–2452.
2009–2011年
Weihang Ji, David Panus, R. Noelle Palumbo, Rupei Tang, Chun Wang*, Poly(2-aminoethyl methacrylate) with well-defined chain length for DNA vaccine delivery to dendritic cells, Biomacromolecules 2011, 12, 4373–4385.
Rupei Tang, Weihang Ji, David Panus, R. Noelle Palumbo, Chun Wang*, Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells, Journal of Controlled Release 2011, 151, 18–27.
Rupei Tang, Weihang Ji, Chun Wang*, Synthesis and characterization of new poly(ortho ester amidine) copolymers for non-viral gene delivery, Polymer 2011, 52, 921–932.
Rupei Tang, Weihang Ji, Chun Wang*, pH-Responsive micelles based on amphiphilic block copolymers bearing ortho ester pendants as potential drug carriers, Macromolecular Chemistry and Physics 2011, 212, 1185–1192.
Rupei Tang, R. Noelle Palumbo, Lakshmi Nagarajan, Emily Krosgard, Chun Wang*, Well-defined block copolymers for gene delivery to dendritic cells: probing the effect of polycation chain-length, Journal of Controlled Release 2010, 142, 229–237.
Rupei Tang, Weihang Ji, Chun Wang*, Amphiphilic block copolymers bearing ortho ester side-chains: pH-dependent hydrolysis and self-assembly in water, Macromolecular Bioscience 2010, 10, 192–201.
Rupei Tang, R. Noelle Palumbo, Weihang Ji, Chun Wang*, Poly(ortho ester amides): acid-labile temperature-responsive copolymers for potential biomedical applications, Biomacromolecules 2009, 10, 722–727.