姓名：刘琳
邮箱：liulin@ahu.edu.cn
职称：教授
地址：安徽省合肥市经开区九龙路111号
邮政编码:230601
科学领域描述：
实验室采用结构生物学、主要是生物大分子晶体学的方法，在原子尺度上研究细胞内重要分子机器的组装和调控机制。实验室近期开展了叶绿素合成途径中的酶及其调控蛋白的结构生物学研究。主要围绕谷氨酰-tRNA还原酶和镁螯合酶，探讨该途径中两个关键节点的催化与调控的分子基础。实验室也开展了对金属蛋白和蛋白-核酸相互作用的研究。
主要成员：
博士后：王晓
博士：潘伟民
硕士：高永山 王艳丽
主要研究方向：
（1）光合色素代谢的分子基础；（2）金属蛋白的结构与功能；（3）蛋白-核酸的相互作用。
研究项目：
（1）面上项目** “植物5-氨基乙酰丙酸合成中GluTR及其调控蛋白的结构基础”；（2）面上项目** “植物叶黄质合成中细胞色素P450酶的结构与机理研究”。
主要发表文章：
2016
Dong W,Wang J,Niu G,ZhaoS,LiuL*. Crystal structure of thezinc-boundHhoAprotease from Synechocystis sp. PCC 6803. FEBS Lett., 2016, 590(19):3435-3442.
　　Zhao S, Wang X, Niu G, Dong W, Wang J, Fang Y, Lin Y, LiuL*. Structural basis for copper/silver binding by metallochaperone CopM. ActaCrystallogr. D Struct. Biol., 2016, 72(9): 997-1005.
　　Wang X, Liu L*. Crystal structure and catalytic mechanismof 7-hydroxymethyl chlorophyll a reductase. J. Biol. Chem., 2016, 291(25): 13349-13359.
　　Fang Y, Zhao S, Zhang F, Zhao A, Zhang W, Zhang M, Liu L*.The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex withFLU and GluTR-binding protein. Sci. Rep., 2016, 6: 19756.
2011-2015
　　Chen X, Pu H, Fang Y, Wang X, Zhao S, Lin Y, Zhang M, DaiH, Gong W*, Liu L*. Crystal structure of the catalytic subunit of magnesiumchelatase. Nat. Plants, 2015, 1(9): 15125.
　　Chen X, Pu H, Wang X, Long W, Lin R, Liu L*. Crystalstructures of GUN4 in complex with porphyrins. Mol. Plant., 2015, 8(7): 1125-1127.
　　Zhang M, Zhang F, Fang Y, Chen X, Chen Y, Zhang W, Dai H,Lin R, Liu L*. The non-canonical tetratricopeptide-repeat (TPR) domain ofFluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase. J.Biol. Chem., 2015, 290(28): 17559-17565.
　　Feng J, Zhao S, Chen X, Wang W, Dong W, Chen J, Shen JR,Liu L*, Kuang T*. Biochemical and structural study of Arabidopsis hexokinase 1.Acta Crystallogr. D Biol. Crystallogr., 2015, 71(2): 367-375.
　　Chen X, Wang X, Feng J, Chen Y, Fang Y, Zhao S, Zhao A,Zhang M, Liu L*. Structural insights into the catalytic mechanism ofSynechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J. Biol.Chem., 2014, 289(37): 25690-25698.
　　Zhao A, Fang Y, Chen X, Zhao S, Dong W, Lin Y, Gong W,Liu L*. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complexwith its stimulator protein. Proc. Natl. Acad. Sci. USA, 2014, 111(18): 6630-6635.
　　Sun W, Gao F, Fan H, Shan X, Sun R, Liu L*, Gong W*. Thestructures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrAproteases. Acta Crystallogr. D Biol. Crystallogr., 2013, 69(5): 830-837.
　　Sun R, Fan H, Gao F, Lin Y, Zhang L, Gong W*, Liu L*.Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligandlocking the hexameric resting state. J. Biol. Chem., 2012, 287(44):37564-37569.
2010年以前
　　Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM,Davies DR*. Structural basis of toll-like receptor 3 signaling with double-strandedRNA. Science, 2008, 320(5874): 379-381.
　　Wang M, Liu L, Wang Y, Wei Z, Zhang P, Li Y, Jiang X, XuH, Gong W*. Crystal structure of homoserine O-acetyltransferase from Leptospirainterrogans. Biochem. Biophys. Res. Commun., 2007, 363(4): 1050-1056.
　　Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W*. Crystalstructure of human coactosin-like protein. J. Mol. Biol., 2004, 344(2): 317-323.
　　Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W*. Expression,purification and preliminary crystallographic studies of human coactosin-likeprotein. Acta Cryst. D Biol. Crystallogr., 2004, 60(9): 1651-1653.