导师简介-范国荣
范国荣,男,博士,教授,生药学硕士生导师。
一、个人简历
1965年9月生,浙江慈溪人。1988年7月毕业于上海中国人民解放军第二军医大学,获医学学士学位。1996年6月在南京中国药科大学获药物分析学博士学位。1997年3月至1999年3月在南京大学化学博士后流动站开展生物微量检测新方法的研究工作。现为中国人民解放军第二军医大学药学院药物分析学教研室主任,全军药物分析学重点实验室、上海市药物(中药)代谢产物研究重点实验室和上海市药物代谢研究中心(中药代谢研究方向)的学科带头人;兼任中国药学会高级会员,上海市药理学会药代动力学专业委员会副主任委员,上海市药学会药物分析专业委员会委员、秘书,全军药物分析专业委员会副主任委员。
二、主要研究方向及科研情况
长期从事现代药物(中药)分析学、药物(中药)代谢动力学的教学和科研工作,在生物药物分析、手性药物分析、药物代谢分析与中药配伍分析以及现代宏量分离制备与微分离分析新技术新方法等方面有较深入的研究。近五年来获军队、地方省部级科技进步奖3项;主持或参与新药研发20余项,获新药证书10余项;主持科技部“十二五”军队特需药品质量研究技术平台、“十一五”重大新药创制专项“综合性新药研究开发技术大平台”—临床前药物代谢动力学技术平台、国家“十五”重大科技专项“创新药物和中药现代化”863项目博士基金、科技部中国比利时政府间合作计划、国家自然科学基金面上项目、上海市科委基础研究重点项目、上海市科委生物医药研究项目、上海市科委中药现代化攀登计划、上海市科委国际合作计划、上海市自然科学基金、等共10余项。研究成果申请国家发明专利10余项,其中8项获得授权、4项已公开。在国际、国内学术刊物上发表科研论文150余篇,其中以第一作者和通讯作者发表SCI(E)论文70余篇,总影响因子超过170(2009IF);主编、副主编药学本科、研究生教材及学术著作6部。
三、发表主要学术论文
1.????? Chen Wang, Jiangrui Zhou, Shuowen Wang, Mingliang Ye, Chunlei Jiang, Guorong Fan, Hanfa Zou.Combined comparative and chemical proteomics on the mechanisms of levo- tetrahydropalmatine-induced antinociception in the formalin test. J Proteome Res,2010, 9(6): 3225–3234. (通讯作者, 2009IF 5.132)
2.????? Chen Wang, Jiangrui Zhou, Shuowen Wang, Mingliang Ye, Guorong Fan, Hanfa Zou, Chunlei Jiang. Shotgun approach based comparative proteomic analysis of levo-tetrahydropalmatine-induced apoptosis in hepatocytes. Toxicol Lett,2010, 194:8-15. (通讯作者, 2009IF 3.479)
3.????? Chen Wang, Shuowen Wang, Guorong Fan, Hanfa Zou, Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem, 2010, 396:1731-1740. (通讯作者, 2009IF 3.48)
4.????? Hua Wei, Jun Wen, Rui Xie, Houwen Lin, Guorong Fan, Yutian Wu, Quantitative determination of Phakellistatin 13, a new cyclic heptapeptide, in rat plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. Anal Bioanal Chem, 2009, 395:1461-1469. (通讯作者, 2009IF 3.48)
5.????? Ning Sun, GuoCai Lu, Mei Lin, Guorong Fan, Yutian Wu, High-throughput quantification of a novel thiazolidinedione MCC-555 in rat plasma by ultra-fast liquid chromatography and its application in pharmacokinetic studies. Talanta, 2009,78:506-512. (通讯作者, 2009IF 3.29)
6.????? Lingli Zhang, Jun Wen, Yaju Pan, Zhen Li, Guorong Fan, Yutian Wu, Determination of ulifloxacin, the active metabolite of prulloxacin, in human plasma by a 96-well format solid-phase extraction and capillary zone electrophoresis. J Chromatogra. B., 2008, 872:172-176. (通讯作者, 2009IF 2.777)
7.????? N Jia, X Liu, Jun Wen, LY Qian, XH Qian, Yutian Wu, Guorong Fan, A proteomic method for analysis of CYP450s protein expression changes in carbon tetrachloride induced male rat liver microsomes. Toxicology, 2007, 237: 1-11. (通讯作者, 2009IF 3.241)
8.????? Tingting Zhou, Bin Chen, Guorong Fan, Yifeng Chai, Yutian Wu, Application of high-speed counter-current chromatography coupled with high-performance liquid chromatography-diode array detection? for the preparative isolation and purification of hyperoside from Hypericum perforatum with on-line purity monitoring. J Chromatogr A, 2006, 1116:97-101. (通讯作者, 2009IF 4.101)
9.????? Jinyong Peng, Guorong Fan, Yutian Wu, Preparative isolation of four new and two known flavonoids from the leaf of Patrinia villosa Juss. by counter-current chromatography and evaluation of their anticancer activities in vitro. J Chromatogr A, 2006, 1115:103-111. (通讯作者, 2009IF 4.101)
10.? Tingting Zhou, Guorong Fan, Zhanying Hong, Yifeng Chai, Yutian Wu, Large-scale isolation and purification of geniposide from the fruit of Gardenia jasminoides Ellis by high-speed counter-current chromatography. J Chromatogr A, 2005, 1100:76-80. (通讯作者, 2009IF 4.101)
11.? Xin Zhou,Jinyong Peng, Guorong Fan, Yutian Wu, Isolation and purification of flavonoid glycosides from trollius ledebouri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase. J Chromatogr A,2005, 1092:216-221. (通讯作者, 2009IF 4.101)
四、2011年在研课题
1、2010ZXJ0900X-003-003,军队特需药品质量控制技术平台,193万元,2010.01-2011.12,科技部军特药保密专项
2、30873431,基于生物活性蛋白分子识别的薏苡附子败酱散有效部位群体内吸收与代谢特征研究,28万元,2009.01-2011.12,国家自然科学基金项目
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