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安徽中医药大学药学院导师教师师资介绍简介-吴欢简介.doc
/2021-05-01
吴欢,1985年生,男,中国药科大学药物分析学博士,博士后,硕士生导师。主要承担本科生《药物分析》、《药物色谱分析》、《体内药物分析》和研究生《蛋白质组学与代谢组学》等专业课程的教学工作。主持国家自然科学基金青年项目、省高校自然科学基金重点项目、省科技重大专项子课题、省博士后研究人员科研活动资助项目、江苏省教育厅创新基金各1项,参与国家自然科学基金7项。获省科技进步二等奖、省级教学成果二等奖、省中医药学会一等奖各1项,获得安徽省药学会优秀学术论文奖5项。以一作和通讯作者在Phytomedicine、Journal of Proteome Research、Journal of Ethnopharmacology、JPBA等杂志发表科研论文12篇。担任Pharmaceutics、Experimental and Therapeutic Medicine、中国药理学通报审稿专家。
一、主持或参加科研项目
(1) 国家自然基金青年科学项目,81903765,靶标代谢组经时谱效关系探究芪玉三龙汤抑制非小细胞肺癌药效物质基础,2020/01-2022/12,主持
(2) 安徽省高等学校自然科学基金重点项目,KJ2019A0478,整合非靶标和靶标代谢组研究芪玉三龙汤抑制非小细胞肺癌作用机理及药效物质,2019/01-2020/12,主持
(3) 国家自然科学基金面上项目,81874360,栀子苷双靶调控SphK1-S1P-S1PR1和Ras-Erk1/2信号转导干预类风湿性关节炎滑膜微环境炎症反应,2019/01-2022/12,参加
(4) 国家自然科学基金面上项目,81872976,基于中药配位化学理论探究复方肝豆汤通过驱铜途径治疗肝豆状核变性的药效物质基础,2019/01-2022/12,参加
(5) 安徽省博士后研究人员科研活动资助项目,2017B193,基于UPLC-QTOF-MSE系统辨识策略研究华蟾素片中化学成分及其体内整体代谢轮廓,2017/08-2019/07,主持
二、近五年代表性学术论文
(1) Xiang Zhan, Huan Wu*, Hong Wu*. Joint synovial fluid metabolomics method to decipher the metabolic mechanisms of adjuvant arthritis and Geniposide intervention [J]. Journal of Proteome Research, 2020, 19(9): 3769-3778.(中科院分区2区)
(2) Huan Wu*, Lina Wang, Xiang Zhan, et al. A UPLC-Q-TOF/MS-based plasma metabolomics approach reveals the mechanism of Compound Kushen Injection-based intervention against non-small cell lung cancer in Lewis tumor-bearing mice [J]. Phytomedicine, 2020, 76: 153259.(中科院分区1区,Top期刊)
(3) Xiang Zhan, Huan Wu*, Hong Wu, et al. Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control [J]. Journal of Ethnopharmacology, 2020, 246: 112178.(中科院分区1区,Top期刊)
(4) Jun Fu, Hong Wu*, Huan Wu*, et al. Chemical and metabolic analysis of Achyranthes bidentate saponins with intestinal microflora-mediated biotransformation by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry coupled with metabolism platform, Journal of Pharmaceutical and Biomedical Analysis, 2019, 170: 305-320.(中科院分区2区)
(5) Huan Wu, Yang Chen, Qinglin Li, et al. Intervention effect of Qi-Yu-San-Long Decoction on Lewis lung carcinoma in C57BL/6 mice: Insights from UPLC–QTOF/MS-based metabolic profiling, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2018, 1102-1103: 23-33.(中科院分区2区)
(6) Huan Wu#, Yang Chen#, Zegeng Li*, et al. Untargeted metabolomics profiles delineate metabolic alterations in mouse plasma during lung carcinoma development using UPLC-QTOF/MS in MSE mode, Royal Society Open Science, 2018, 5: 181143.(中科院分区3区)
(7) Yang Chen, Huan Wu, Xinheng Wang, et al. Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways, Biomedicine & Pharmacotherapy, 2018, 101: 311-321.(中科院分区2区)
(8) Huan Wu*, Dan Wang, Jin Meng, et al. A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol-induced hepatic steatosis, Analytical Methods, 2017, 9(4): 586-592.(中科院分区3区)
(9) Huan Wu, Fang Feng*, Untargeted metabolomic analysis using LC-TOF/MS and LC-MS/MS for revealing metabolic alterations linked to alcohol-induced hepatic steatosis in rat serum and plasma, Rsc Advances, 2016, 6(34): 28279-28288.(中科院分区3区)
(10) Huan Wu, Xixi Li, Xuemei Yan, et al. An untargeted metabolomics-driven approach based on LC-TOF/MS and LC-MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma, Journal of Pharmaceutical and Biomedical Analysis, 2015, 115: 315-322.(中科院分区2区)
三、获奖情况
(1) 吴欢(6/8); 基于临床疗效的中药华蟾素关键技术系统研究模式的建立及其应用, 安徽省人民政府, 安徽省科学技术进步奖, 二等奖(J-2019-2-126-R6)
(2) 吴欢(2/11); 基于药效-药动-机理结合模式:栀子苷调控实验性关节炎G蛋白偶联受体脱敏及MAPKs信号转导, 安徽省中医药学会, 安徽省中医药科学技术奖, 一等奖(2019-1-R2)
(3) 吴欢(4/8); 地方高等医药院校药物分析硕士人才创新能力培养的研究与实践, 安徽省教育厅, 安徽省高等学校省级教学成果奖, 二等奖(2019jxcgj274-4)
(4) 黄梦文,吴欢;基于UPLC-Q-TOF/MS技术分析复方苦参注射液化学成分及其抑制非小细胞肺癌的代谢组学研究,安徽省药理学会,2020年学术年会青年优秀论文一等奖
(5) 2017年-2019年连续3年获得药学院“优秀指导教师”
四、研究方向
1. 药物分析新技术和方法研究
2. 药物作用有效性与活性成分相关性研究
3. 中药质量控制与评价
五、联系方式
电话:0551-65169051(手机:18154125663)
邮箱:wuhuancpu@ahtcm.edu.cn
QQ:273387059