导师简介-吴家文

? 1991年毕业于华东师范大学生物系，获理学学士学位，2002-2007年在中国科学技术大学、微尺度科学国家实验室、生命科学院硕博连读，获生化与分子生物学专业博士学位。2008-2014年在美国范德比尔特大学医学中心生物化学和神经病学系从事博士后研究、任博士后研究员及研究讲师职位。
主要研究方向为基因工程（包括基因重组、基因突变）、重组蛋白在微生物体内的表达及纯化、蛋白质结构及功能的研究、蛋白质相互识别以及相互作用的机制研究、基于蛋白质结构的药物开发以及抑制剂的筛选、有毒中药对癌症的作用机制研究、中草药基因资源及蛋白质药物开发等。
从2002年开始主要从事位于国际前沿的人类基因组计划后基因组工程—蛋白质结构与功能研究；主持或参与了国家自然科学基金研究项目、安徽省自然基金项目、国家重点基础研究发展计划、中国科学院基金研究项目和美国国立卫生研究院（NIH）、美国国立神经病及中风研究所（NINDS）、美国政府VA的多项研究项目；主要研究成果发表于The Journal of Biological Chemistry、Annals of Neurology、 BiochemBiophys Res Commun、 BMC Structural Biology和Proteins等国际著名学术期刊；在美国期间多次参加国际学术会议，并发表会议论文；参与了国际著名期刊如Plus One, International Journal of Nanomedicine的审稿工作；是著名的F1000和 Sigma Xi（The Scientific Research Society）的会员,安徽省生化与分子生物学学会理事，生物学杂志编委。
联系方式E-mail: wu-jiawen@hotmail.com 0551-65169752
近期发表的论文：
1. Miaomiao Liu, Xiqiang Wang, Dengke Yinb, Qingshan Yang, Yi Liao, Jiawen Wu*. Molecular cloning and expression analysis of two lectin genes in Sophora flavescens. GENE, 2016.11 Submitted.
2. 王希强，尹登科，储俊， 吴家文*，蛇床子三螺旋转录因子基因的克隆与表达分析，生物学杂志，第33卷，总第191期，2016（3），P24。
3. Jiawen Wu, Dungeng Peng, Yang Zhang, Zhenwei Lu, Markus Voehler,Charles R. Sanders, Jun Li. Biophysical Characterization of Interactions between the C-termini of Peripheral Nerve Claudins and the PDZ1 Domain of Zonula Occludens. Biochem Biophys Res Commun. 02/2015; 459(1). DOI:?10.1016/j.bbrc.2015.02.075
4. Jiawen Wu, Dungeng Peng, Markus Voehler, Charles R. Sanders, Jun Li. Structure and Expression of a Novel Compact Myelin Protein - Small VCP-Interacting Protein (SVIP). Biochem Biophys Res Commun.?2013 Oct 11;440(1):173-8
5. Jiasong Guo, Yang Zhang, Leiming Wang, Jiawen Wu, Sezgi Arpag, Bo Hu, Beat A. Imhof, Bruce D. Carter, Ueli Suter, Jun Li. Abnormal Junctions and Permeability of Myelin in PMP22 Deficient Nerves.?Ann Neurol, 2014, 75(2):255-265
6. Jiawen Wu, Yinshan Yang, Jiahai Zhang, Peng Ji, Wenjing Du, Peng Jiang, Dinghai Xie, Hongda Huang, Mian Wu, Guangzhao Zhang, Jihui Wu, and Yunyu Shi. Domain-swapped Dimerization of the Second PDZ Domain of ZO2 May Provide a Structural Basis for the Polymerization of Claudins. J Biol Chem?2007?Dec?7; 282(49); 35988-35999.
7.Jiawen Wu, Solution Structure and Functional Study of the Second PDZ Domain of Human ZO2. http://www.dissertationtopic.net/doc/1643930
8. Hongda Huang, Jiahai Zhang, Weiqun Shen, Xingsheng Wang, Jiawen Wu, Jihui Wu, Yunyu Shi. Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails. BMC Structural Biology 2007, 7:57
9. Hui Chen, Shuilong Tong, Xu Li, Jiawen Wu, Zhiqiang Zhu, Liwen Niu, and Maikun Teng. Structure of the second PDZ domain from human zonula occludens 2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 April 1; 65(Pt 4): 327–330
10. Peng Ji, Guang Yang, Jiahai Zhang, Jiawen Wu, Zhengjun Chen, Qingguo Gong, Jihui Wu, and Yunyu Shi. Solution structure of the second PDZ domain of Zonula Occludens 1. Proteins: Structure, Function, and Bioinformatics Volume 79, Issue 4, pages 1342–1346, April 2011
对PDB和BMRB蛋白质数据库的贡献：
1. Accession: 2OSG?? Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2
Authors: Wu, J.W., Yang, Y.S., Zhang, J.H., Ji, P., Wu, J.H., Shi, Y.Y.
Release Date: 2007-09-25 Classification: Cell Adhesion????
2. Accession: 2JWE? ?Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping
Authors: Ji, P., Wu, J.W., Zhang, J.H., Yang, Y.S., Wu, J.H., Shi, Y.Y.
Release Date: 2007-10-30?Classification: Cell Adhesion????
3. Assigned NMR chemical shifts for Small VCP-Interacting Protein (SVIP). Biological Magnetic Resonance Data Bank ( BMRB), Entry number 19485
Authors: Jiawen Wu, Jun Li
期刊审稿：（Journal Reviewer）:
Plus One，during 2016
Virtual Judge for Conrad Innovation Awards, during 2013-a judge for the 2013-2014 Spirit of Innovation Challenge
International Journal of Nanomedicine, during 2013
F1000 Associate Faculty Member, since October 2011
Chinese Journal of Biology (ISSN 2095-1736), since 2006
荣誉协会（Honorary Societies）:
F1000、Sigma Xi 会员
安徽省生化与分子生物学学会理事
生物学杂志编委