刘李简介

刘李，男，1981年1月出生，博士；中国药科大学药学院副院长，教授，博士生导师。主要研究方向：研究方向：疾病状态下药物代谢动力学、中药药物代谢动力学和创新药物的药代动力学研究。

1、主要社会兼职情况
现为《中国药科大学学报》、《Mini-Reviews in Medical Chemistry》、《International Journal of Pharmaceutics》等学术期刊的审稿人。

2、近5年来主持科研项目情况
1. 国家自然科学基金面上项目、81473273、?基于CYP3A等CYP450酶活性诱导诠释阿托伐他汀等他汀类药物诱发新生糖尿病和加重糖尿病症状的作用及机制、2015/01-2018/12、70万元、在研、主持。
2. 国家自然科学基金青年基金，81102503、基于胰高血糖素样肽-1释放调控诠释人参二醇型皂苷抗糖尿病作用及其机制、2011/01-2013/12、25万元、已结题、主持。

3、 近5年来发表有代表性学术论文（*通讯作者）
1. Li J, Guo HF, Liu C, Zhong Z, Liu L*, Liu XD*. Prediction of Drug Disposition in Diabetic Patients by Means of a Physiologically Based Pharmacokinetic Model. Clin Pharmacokinet. 2015; 54(2):179-93.
2. Liu L, Liu XD*. Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances. Front Pharmacol. 2014; 5:273.
3. Zhang J, Zhang M, Sun B, Li Y, Xu P, Liu C, Liu L*, Liu X*. Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood-brain barrier through NF-κB. J Neurochem. 2014; 131(6):791-802.
4. Xu D, Li F, Zhang M, Zhang J, Liu C, Hu MY, Zhong ZY, Jia LL, Wang DW, Wu J, Liu L*, Liu XD*. Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes. Acta Pharmacol Sin. 2014; 35(9): 1215-25.
5. Liu C, Hu MY, Zhang M, Li F, Li J, Zhang J, Li Y, Guo HF, Xu P, Liu L*, Liu XD*. Association of GLP-1 secretion with anti-hyperlipidemic effect of ginsenosides in high-fat diet fed rats. Metabolism. 2014; 63(10): 1342-51.
6. Li F, Zhang M, Xu D, Liu C, Zhong ZY, Jia LL, Hu MY, Yang Y, Liu L*, Liu XD*. Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure. Acta Pharmacol Sin. 2014; 35(6): 792-805.
7. Li J, Wang X, Liu H, Guo H, Zhang M, Mei D, Liu C, He L, Liu L*, Liu X*. Impaired hepatic and intestinal ATP-binding cassette transporter G5/8 was associated with high exposure of β-sitosterol and the potential risks to blood-brain barrier integrity in diabetic rats. J Pharm Pharmacol. 2014; 66(3):428-36.
8. Hu N, Hu MY, Duan R, Liu C, Guo HF, Zhang M, Yu YL, Wang XT, Liu L*, Liu XD*. The increased levels of fatty acids contributed to induction of hepatic CYP3A4 activityinduced by diabetes. An in vitro evidence from HepG2 cell and Fa2N-4 cell lines. J Pharmacol Sci. 2014; 124(4):433-44.
9. Jia LL, Zhong ZY, Li F, Ling ZL, Chen Y, Zhao WM, Li Y, Jiang SW, Xu P, Yang Y, Hu MY, Liu L*, Liu XD*. The aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic Acid in rats. J Pharmacol Sci. 2014;124(4):468-79.
10. Guo H, Liu C, Li J, Zhang M, Hu M, Xu P, Liu L*, Liu X*. A mechanistic physiologically based pharmacokinetic-enzyme turnover model involving both intestine and liver to predict CYP3A induction-mediated drug-drug interactions. J Pharm Sci. 2013; 102(8): 2819-36.
11. Liu C, Zhang M, Hu MY, Guo HF, Li J, Yu YL, Jin S, Wang XT, Liu L*, Liu XD*. Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides. J Endocrinol. 2013; 217(2):185-96.
12. Yu Y, Wang X, Liu C, Yao D, Hu M, Li J, Hu N, Liu L*, Liu X*. Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. Toxicol Appl Pharmacol. 2013; 266(3): 375-84.
13. Liu H, Liu L [Co-first author], Li J, Mei D, Duan R, Hu N, Guo H, Zhong Z, Liu X*. Combined Contributions of Impaired Hepatic CYP2C11 and Intestinal Bcrp Activities and Expressions to Increased Exposure of Oral Glibenclamide in Streptozotocin-induced Diabetic Rats. Drug Metab Dispos. 2012; 40(6): 1104-12.
14. Duan R, Hu N, Liu HY, Li J, Guo HF, Liu C, Liu L*, Liu XD*. Biphasic regulation of P-glycoprotein function and expression by NO donors in Caco-2 cells. Acta Pharmacol Sin. 2012 Jun;33(6):767-74. [IF: 2.354]
15. Yao D, Liu L [Co-first author], Jin S, Li J, Liu XD*. Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats. Neuroscience. 2012; 227: 283-92.
16. Liu L, Yu YL, Liu C, Wang XT, Liu XD, Xie L. Insulin deficiency induces abnormal increase in intestinal disaccharidase activities and expression under diabetic states, evidences from in vivo and in vitro study. Biochem Pharmacol. 2011; 82(12): 1963-70.
17. Liu L, Pan X, Liu HY, Liu XD, Yang HW, Xie L, Cheng JL, Fan HW, Xiao DW. Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacol Sin. 2011; 32(10): 1285-93.
18. Liu L, Ju HL, Zhang J, Liang Y, Liu XD, Xie L, Wang GJ. Development and validation of an LC-MS/MS method for determination of vorinostat in beagle dog plasma and its application to a pharmacokinetic study. Asian J Pharmacodyn Pharmacokinet. 2010; 10(3): 209-219.
19. Liu L, Yu YL, Yang JS, Li Y, Liu YW, Liang Y, Liu XD, Xie L, Wang GJ. Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn Schmiedebergs Arch Pharmacol. 2010; 381(4): 371-81.
20. Liu L, Deng YX, Liang Y, Pang XY, Liu XD, Liu YW, Yang JS, Xie L, Wang GJ. Increased oral AUC of baicalin in streptozotocin-induced diabetic rats due to the increased activity of intestinal β-glucuronidase. Planta Med. 2010; 76(1):70-5.

4、近年来获厅级以上奖励情况
1) 2011年/江苏省普通高校本专科优秀毕业设计论文优秀三等奖/基于类胰高血糖素样肽1研究加替沙星所致的糖代谢紊乱现象/指导教师

5、指导研究生情况
2014年开始指导药代动力学专业硕士研究生。协助指导已毕业博士生6名、硕士生12名，现正在独立指导硕士研究生1人。