左莉职称：副教授
联系电话：**
email：lizuo1981@163.com
研究方向：1.肠道炎症性疾病2.紧密连接与肠道屏障功能3.肿瘤免疫治疗引起的结肠炎的预防和治疗

个人简历科研项目论文专著专利与技术许可荣誉与奖励
教育经历
2009-9 至 2014-7, 安徽医科大学, 分子药理学, 博士, 导师: 汪渊
2003-9 至 2006-7, 安徽医科大学, 生物化学与分子生物学, 硕士, 导师: 汪渊
1999-9 至 2003-7, 安徽医科大学, 生物技术, 学士科研与学术
工作经历
2018-11 至现在, 安徽医科大学, 基础医学院, 副教授
2017-11 至现在, 哈佛医学院附属布莱根和妇女医院, 病理部, 博士后
2009-7 至 2017-10, 安徽医科大学, 基础医学院, 讲师
2006-7 至 2009-6, 安徽医科大学, 基础医学院, 助教



1. 国家自然科学基金委员会，面上项目，**，阻断MLCK1 与 FKBP8 相互作用缓解免疫检查点抑制子治疗引起的结肠炎， 2021.01-2024.12，55 万元， 在研，主持
2. 国家自然科学基金委员会，青年基金，**，抑制 FKBP8 介导的 MLCK1 转运对TNF 诱导肠道粘膜损伤修复的影响及机制研究，2019 年 01 月至 2021 年12 月，21 万元，在研，主持



1. Zuo L, KuoWT [and] Turner JR. Tight junctions as targets [and] effectors of mucosal immune homeostasis. Cellular [and] Molecular Gastroenterology [and] Hepatology.2020;10(2):327-340.


2. Feng Cao, Le Zhu, Jing Zhang, PawinPongkorpsakol, Wei-Ting Kuo, Jerrold R. Turner, Qing Zhou, Yuan Wang, Feihu Chen, Yehai Liu, Li Zuo. Myosin light chain kinase is a potential target f[or] hypopharyngealcancer treatment. Biomed Pharmacother. 2020; 131:110665.


3. PawinPongkorpsakol, Jerrold R Turner, LiZuo. Culture of Intestinal Epithelial Cell Monolayers [and] Their Use in Multiplex Macromolecular Permeability Assays f[or] In Vitro Analysis of Tight Junction Size Selectivity CurrProtocImmunol. 2020 Dec;131(1):e112.


4. Nalle SC, Zuo L, Ong MLDM, Singh, Worthylake A, Choi WS, Manresa MC, Southworth A, Edelblum KL, Baker GJ, Joseph NE, Savage PA [and] Turner JR.Graft-versus-host-disease propagation depends on increased intestinal epithelial tight junction permeability. The Journal of Clinical Investigation. 2019,129(2): 902-914.


5. Kuo WT, Shen L, Zuo L, Nitesh S, Ong MLDM, Wu LC, Zha JM, Edelblum KL, Wang YT, Wang YM, Nilsen SP, Turner JR. Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression. Gastroenterology, 2019, 157(5): 1323-1337


6. Zuo L,Yang X, Lu M, Hu R, Zhu H, Zhang S, Zhou Q, Chen F, Gui S, Wang Y. All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Down-regulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway. Nutr Cancer. 2016;68(7):1225-33.


7. Zuo L, Zhang SM, Hu RL, Zhu HQ, Zhou Q, Gui SY, Wu Q, Wang Y. CorrelationbetweenexpressionanddifferentiationofEndocanincolorectalcancer.Wo rld J Gastroenterol.2008;14(28):4562-8.


8. Zuo L, Lu M, Zhou Q, Wei W, Wang Y. Butyrate suppresses proliferation [and] migration of RKO colon cancer cells though regulating Endocan expression by MAPK signaling pathway. Food ChemToxicol.2013;62:892-900


9. Yang XP, Zou DB, Tang ST, Fan T, Su H, Hu R, Zhou Q,Gui S, ZuoL, Wang Y. Ameliorativeeffectofmelatoninagainstincreasedintestinalpermeabilityindiabeticrats: possibleinvolvementofMLCKdependentMLCphosphorylation.MolCellBiochem.20 16;416(1-2):23-32.（CorrespondingAuthor）


10. Zou DB, Wei X, Hu RL,Yang XP , Zuo L, Zhang SM, Zhu HQ, Zhou Q, Gui SY , Wang Y. Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPK. Asian Pac J Cancer Prev. 2015;16(14):5835-42.


11. hangSM,ZuoL,GuiSY,ZhouQ,WeiW,WangY.Inductionofcelldifferentiation[and] romotionofEndocangeneexpressioninstomachcancerbymelatonin.MolBiolRep.20 12; 39:2843-2849.(Co-Author)


12.ZuoL,ZhangSM,HuRL,ZhuHQ,Cheng XW,Zhou Q,Gui SY,WuQ, Wang Y.Theexpressionofendothelialcellspecificmolecule-1incolorectalcancer.ActaUniv ersitatisMedicinalisAnhui.200742(6):620-622.(Chinese)




2016年安徽省教坛新秀
2015年安徽医科大学教坛新秀