石宣明职称：教授
联系电话：--
email：xuanming.shi AT ahmu.edu.cn
研究方向：1.二代测序整合分析组蛋白甲基化和lncRNA调控髓母细胞瘤发生发展的分子机理;2.髓母细胞瘤发生发展中的脂肪代谢调控;3.单细胞测序分析能量变化过程中肝细胞的变迁

个人简历科研项目论文专著专利与技术许可荣誉与奖励
1995-1999 安徽大学生物化学专业 本科
1999-2001安徽丰原集团新药开发助理工程师
2001-2002 中科院微生物所研究助理
2002-2005 四川农业大学和中科院微生物所联合培养生物化学与分子生物学 硕士
2005-2009德国罗斯托克大学和来布尼兹动物研究所分子生物学博士
2010-2014 美国得州大学西南医学中心 生理和发育系 博士后
2015-2017 美国得州大学西南医学中心 生理系 讲师
2017-2020美国得州大学西南医学中心 分子遗传系Brown&Goldstein实验室 讲师
2020-至今安徽医科大学基础医学院生化教研室 教授
石宣明教授博士阶段研究脂肪酸代谢乙酰辅酶A羧化酶的抑制机理，后从事小脑发育及髓母细胞瘤发生发展的表观遗传学调控机理研究，主要论文发表在Nature Communications、PNAS、Oncogene、Oncogenesis、Plos-Biology、BBA-Gene Regulatory Mechanism、BMC-Molecular Biology等国际高影响力杂志上。现从事肿瘤的表观遗传学及代谢调控机制研究，探索小脑及肝脏疾病发生的表观遗传及代谢调控机理，寻找特异性治疗药物。



1.美国国防部，博士后研究基金，GRANT**,染色体重塑因子Brg1在音猥因子信号依赖的髓母细胞瘤生长中的作用机制,2012.9-2015.9，主持，结题


2.国家自然科学基金面上项目，**，组蛋白去甲基化酶UTX在髓母细胞瘤发生发展中的功能和机制研究，2021.01-2024.12，主持，在研





1.Yi, J., Shi, X., Xuan, Z., & Wu, J. (2021). Histone demethylase UTX/KDM6A enhances tum[or] immune cell recruitment, promotes differentiation [and] suppresses medulloblastoma. Cancer Lett, 499, 188-200. doi: 10.1016/j.canlet.2020.11.031


2.Fang F.,Shi, X., Brown M.*, Goldstein J.L.*, Liang G. Growth Hormone Acts on Liver to Stimulate Autophagy, Support Glucose Production, [and] Preserve Blood Glucose in Chronically Starved Mice.Proc Natl Acad Sci U.S.A.(2019) 116(15) 7449-7454


3.Han, Y., Xiong Y.,Shi, X., Wu, J, Zhao Y., Jiang J*. Regulation of Gli ciliary localization [and] Hedgehog signaling by the PY-NLS/karypherin-β2 nuclear import system.PLoS Biology15 (8), e**.


4.Shi, X., Wang, Q., Gu, J., Xuan, Z., Wu, J.*, Brg1/SmarcA4 Coordinates Genetic [and] Epigenetic Networks Underlying Shh-type Medulloblastoma Development.Oncogene2016 Apr 11. doi: 10.1038/onc.2016.108.


5.Shi, X., Zhan, X., Wu, J.#, A Positive Feedback Loop between Gli1 [and] Tyrosine Kinase Hck Amplifies Shh Signaling Activities in Medulloblastoma.Oncogenesis(2015) 4, e176; doi:10.1038/oncsis.2015.38.


6.Zhang, Z., Cao, M., Chang, C., Wang, C.,Shi, X., Zhan, X., Birnbaum, S., Bezprozvanny, I., Huber, K., Wu, J.*, Autism-Associated Chromatin Regulat[or] Brg1/SmarcA4 is Required f[or] Synapse Development [and] MEF2-mediated Synapse Remodeling. Molecular [and] Cellular Biology 2015 Oct 12. pii: MCB.00534-15.


7.Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Wang, R., Wang, C., Ge, K., Wu, J.* (2014). An epigenetic switch induced by Shh signalling regulates gene activation during development [and] medulloblastoma growth.Nature Communications2014; 5:5425.


8.Shi, X., Metges, C.C., [and] Seyfert, H.-M.* (2013) Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle.Gene. 2013 Feb 25;515(2):266-71.


9.Shi, X., Metges, C.C., [and] Seyfert, H.-M.* (2012). Interaction of C/EBP [and] NF-Y factors constrains the promoter IA activity of the bovine acetyl-CoA carboxylase-alpha gene.BMC Molecular Biology2012 Jun 27;13(1):21.


10.#Zhan, X.,#Shi, X., Zhang, Z., Chen, Y., Wu, J.I.* (2011) Dual Role of Brg Chromatin Remodeling Fact[or] in Shh Signaling during Neural Development.Proc Natl Acad Sci U.S.A.2011 Aug 2;108(31):12758-63.
# Co-first author


11.Liu, S.,Shi, X., Guenther, J., Bauer, I., Seyfert, H.-M.* (2011). Lingual Antimicrobial Peptide [and] IL-8 expression are oppositely regulated by the antagonistic effects of NF-kB p65 [and] C/EBPbin Mammary Epithelial Cells.Mol. Immunol.2011 March 48(6-7):895-908.


12.Shi, X., Liu, S., Metges, C.C., [and] Seyfert, H.-M.* (2010). C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle.Biochim. Biophys. Acta-gene regulatory mechanism2010 1799:561-567.


13.Muráni, E., Ponsuksili, S., Seyfert, H.-M.,Shi, X., [and] Wimmers, K.* (2009). Dual effect of a single nucleotide polymorphism in the first intron of the porcine Secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta [and] activation of aberrant splicing.BMC Molecular Biology2009 Oct 21;10(1):96.



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