杨亚男职称：教授
联系电话：**
email：yang.yanan@ahmu.edu.cn
研究方向：1.肿瘤生物学2.靶向和免疫治疗3.表观遗传学

个人简历科研项目论文专著专利与技术许可荣誉与奖励
杨亚男教授，博导，安徽医科大学免疫学系主任。
1993 河南师范大学 本科
2000 中国科学院上海生物化学与细胞生物学研究所 博士
2006 美国MD Anderson癌症中心 博士后
2011 美国MD Anderson癌症中心 讲师
2012 美国梅奥医学院 课题组长
2020 安徽医科大学 基础医学院 教授



1.** 国自然面上项目 赖氨酸羟化酶3促进表皮生长因子受体酪氨酸激酶抑制剂的“获得性耐药性”的机制

1. Peng DH, Kundu ST, Fradette JJ, Diao L, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Mino B, Yang Y, Minelli R, Peoples MD, Bristow CA, Heffernan TP, Carugo A, Wistuba II, Gibbons DL. ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism. Science Translational Medicine. 2019 Mar 13;11(483): eaaq1238.
2. Wang Y, Zhang T, Guo L, Ren T, Yang Y. (2019). Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. International Journal of Biochemistry [and] Cell Biology. 2019; 106:96-106.
3. Zhang T, Guo L, Creighton CJ, Lu Q, Gibbons DL, Yi ES, Deng B, Molina JR, Sun Z, Yang P, Yang Y. (2016). A genetic cell context-dependent role f[or] ZEB1 in lung cancer. Nature Communications. 2016 6:12231.
4. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tum[or] stroma. Journal of Clinical Investigation. 2015 Mar 2;125(3):1147-62.
5. Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, Ungewiss C, Peng DH, Liu X, Lin SH, Thilaganathan N, Wistuba II, Rodriguez-Canales J, McLendon G, Creighton CJ, Kurie JM (2014). ZEB1 Sensitizes Lung Adenocarcinoma Cells to Metastasis Suppression by PI3K-Targeted Therapy. Journal of Clinical Investigation. 124(6): 2696-2708.
6. Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganthan N, Moreira DC, Creighton CJ, Gregory PA, Goodall GJ, Kurie JM. (2011). The Notch Lig[and] Jagged2 Promotes Lung Adenocarcinoma Metastasis Through a miR-200-dependent Pathway in Mice. Journal of Clinical Investigation. 121: 1373-1385.
7. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton C, Demayo FJ, Wistuba II, Kurie JM. (2008). Pten Inactivation Accelerates Oncogenic K-rasinitiated Tumorigenesis in a Mouse Model of Lung Cancer. Cancer Research. 68: 1119-1127.
8. Yang Y, Wislez M, Fujimoto N, Prudkin L, Izzo JG, Uno F, Ji L, Hanna AE, Langley RR, Liu D, Johnson FM, Wistuba I, Kurie JM. (2008). A selective small molecule inhibit[or] of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras. Molecular Cancer Therapeutics. 7(4):952-60.
9. Yang Y, Pan X, Lei W, Wang J, Shi J, Li F, Song JG. (2006). Regulation of transforming growth fact[or] β1-Induced apoptosis [and] epithelial to mesenchymal transition by protein kinase A [and] signal transducers [and] activators of tranion 3. Cancer Research. 66: 8617-8624
10. Yang Y, Pan X, Lei W, Wang J, Song JG. (2006). Transforming growth fact[or] β1 induces epithelial-to-mesenchymal transition [and] apoptosis via a cell cycle-dependent mechanism. Oncogene 25: 7235-7244.1.




2020 安徽医科大学东南****
2021 安徽省人才计划