张冕群


性别：
女
专业名称：
动物繁殖学

研究方向：
哺乳动物卵子成熟；受精及早期胚胎发育的分子基础和环境影响因素

技术职务：
副教授

E-mail：
qq.com

张冕群，女，2019年毕业于南京农业大学动物科技学院熊波教授生殖生物学实验室，获博士学位。2018年至2019年在比利时新鲁汶大学（UCLouvain）医学院进行国家公派博士研究生联合培养。2020年1月起在安徽农业大学担任副教授，硕士生导师。主要从事哺乳动物卵子质量控制的分子机理研究，研究成果：1）染色体黏合相关蛋白通过参与纺锤体检验点功能调控卵子成熟的分子基础，揭示卵子非整倍体形成机制； 2）受精的内在调控机制和外在影响因素，明确受精调节蛋白Oastacin和Juno在其中的作用机理，为解析卵子质量低下引起动物繁殖力下降提供了重要的理论依据。期间参与多项省级和国家级科研项目，共发表SCI论文15篇，其中以第一作者身份在J Pineal Res, FASEB J, Redox Biol, Free Radic Biol Med等主流学术期刊发表SCI论文共6篇。

　科研情况：

1、自然科学基金委员会, 面上项目, **, 利用Ovastacin-mCherry转基因小鼠研究哺乳动物皮质颗粒的动态转运及调控机理, 2016-01至2019-12, 71.6万元, 结题, 参与
2、自然科学基金委员会, 面上项目, **, HDAC3在小鼠卵母细胞发育中的作用及机制研究, 2018-01至2021-12, 60万元, 在研, 参与

　论文论著：

Mianqun Zhang, Xiaoxin Dai, Yajuan Lu, Yilong Miao, Changyin Zhou, Zhaokang Cui, Honglin Liu, Bo Xiong*. Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse. J Pineal Res. 2017: 62. (IF=15.221, 5 year IF=12.197)
Mianqun Zhang†, Yajuan Lu†, Yin Chen†, Yu Zhang, Bo Xiong*. 2020. Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes. Redox Biology. 2020 Jan;28: 101327. (IF=7.793, 5 year IF=9.038)
Mianqun Zhang†, Xiayan ShiYang†, Yuwei Zhang, Yilong Miao, Ying Chen, Zhaokang Cui, Bo Xiong*. Coenzyme Q10 ameliorates the quality of postovulatory-aged oocytes by suppressing oxidative stress. Free Radical Biology and Medicine. 2019: 143. (IF=5.87, 5 year IF=6.401)
Mianqun Zhang, Yilong Miao, Qian Chen, Meng Cai, Wenkang Dong, Xiaoxin Dai, Yajuan Lu, Changyin Zhou, Zhaoakng Cui, Bo Xiong*. BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility. FASEB J. 2018: 32. (IF=5.391, 5 year IF=5.421)
Mianqun Zhang, Xiaoxin Dai, Yajuan Lu, Changyin Zhou, Yilong Miao, Ying Wang, Bo Xiong*. Stag3 regulates microtubule stability to maintain euploidy during mouse oocyte meiotic maturation. Oncotarget. 2017: 8.
Xiaoxin Dai†, Hao Xiong†,Mianqun Zhang†, Shaochen Sun, Bo Xiong*. Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. Oncotarget. 2016 : 7.
Yajuan Lu, Xiaoxin Dai, Mianqun Zhang, Yilong Miao, Changyin Zhou, Bo Xiong*. The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis. Nucleic Acids Res. 2018: 46. ( IF=11.15)
Yajuan Lu, Xiaoxin Dai, Mianqun Zhang, Yilong Miao, Changyin Zhou, Zhaokang Cui, Bo Xiong*. Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis. Nucleic Acids Res. 2017: 45. (IF=11.15)
Yilong Miao, Changyin Zhou, Zhaokang Cui, Mianqun Zhang, ShiYang Xiayan, Xiong Bo. Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress. FASEB J. 2017 Nov 6. (IF=5.498)
Yilong Miao, Changyin Zhou, Zhaokang Cui, Xiayan ShiYang, Yajuan Lu, Mianqun Zhang, Xiaoxin Dai, Bo Xiong*. The protective role of melatonin in porcine oocyte meiotic failure caused by the exposure to benzo(a)pyrene. Human Reproduction. 2017 Nov 3:1-12. (IF=5.02)
Yilong Miao†, Changyin Zhou†, Zhaokang Cui†, Liangsheng Tang, Xiayan ShiYang, Yajuan Lu, Mianqun Zhang, Xiaoxin Dai, Bo Xiong*. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017 Sep 21:1-7.(IF=3.53)
Xiaoxin Dai, Lu Yajuan, Zhang Mianqun, Yilong Miao, Changyin Zhou, Zhaokang Cui, Bo Xiong*. Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion. Hum Reproduction. 2017 Mar 1;32(3):598-606. (IF=5.02)
Xiaoxin Dai, Mianqun Zhang, Yajuan Lu, Yilong Miao, Changyin Zhou, Bo Xiong*. Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin. Biochimica et Biophysica Acta - Molecular Cell Research. 2016 Dec;1863(12): 2934-2941. (IF=5.26)