张劲松
　　性别：男
　　单位：茶与食品科技学院
　　研究方向：营养与毒理；茶与健康
　　技术职务：教授
　　E-mail：zjs@ahau.edu.cn
　　通讯地址：合肥市长江西路130号
　　邮政编码：230036

　　工作经历
　　2009．3至今 安徽农业大学 茶与食品科技学院
　　2002．3─2009．2 中国科学技术大学 化学与材料科学学院
　　2000．3─2002．2 Institute of Food Research，Norwich，UK
　　1999．8─2000．2 中国科学技术大学 化学与材料科学学院
　　1988．9─1999．7 国家烟草专卖局 合肥经济技术学院

　　学习经历
　　2002．9─2004．7 中国科学院 固体物理研究所 博士
　　1985．9─1988．7 安徽农学院 茶业系 硕士
　　1981．9─1985．7 安徽农学院 茶业系 学士

　　荣誉
　　全国优秀教师
　　第三届中国优秀青年科技创业奖

　　研究兴趣
　　茶与健康、茶与硒生物效应相互影响<3，4>（23，26，28），硒研究涉及硒毒性、药效、营养和酶靶。
　　硒毒性：发明纳米硒（ZL97107038．5）并阐述其高安全性（1，2，4-6，9，13，20，24，26），基于纳米硒低毒特征，FDA毒理学研究中心前任主任邀请参编两部毒理学专著<1，2>，纳米硒为卫生部批准的保健食品，属国家级新产品。
　　硒药效：发明硒代硫酸钠与一线化疗药顺铂联用治疗肿瘤（ZL**6．4），在肝癌模型上，顺铂至多取得25%治愈率，联用至少产生75%治愈率（8，15，19，25），Cancer Weekly三次报道该项研究进展。
　　硒营养：发现硒与西兰花中莱菔硫烷协同诱导硫氧还蛋白还原酶，硒与西兰花可能是防癌伴侣（3），BBC News，The Times，The Guardian，Genomics and Genetics Weekly，Cancer Weekly等报道此发现。
　　硒酶靶：基于动物实验，说明硫氧还蛋白还原酶是抗癌药的药靶和毒靶（7，11，12，17，18，21，27），美国Threshold Pharmaceuticals公司邀请评价抗癌新药TH-302药理，发现它抑制该酶活力（22）。

　　专著章节
　　<4> Zhang L, Wu S, Wang D, Wan X, Zhang J*. Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. In: Casciano D, Sahu SC (eds) Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. John Wiley & Sons. Invited chapter in preparation. (* communication author)
　　<3> Zhang L, Zhang Z, Lu Y, Zhang J, Preedy VR. L-theanine from green tea: Transport and effects on health. In: Preedy VR (ed) Tea in Health and Disease Prevention. Academic Press. pp 425-435, 2012.
　　<2> Zhang J*, Spallholz J. Toxicity of selenium compounds and nano-selenium particles. In: Casciano D, Sahu SC (eds) Handbook of Systems Toxicology. John Wiley & Sons. pp 787-802, 2011.
　　<1> Zhang J*. Biological properties of red elemental selenium at nano size (Nano-Se) in vitro and in vivo. In: Sahu SC, Casciano D (eds) Nanotoxicity: From In Vivo and In Vitro Model to Health Risks. John Wiley & Sons. pp 97-114, 2009.

　　论文和论文评审
　　第一或通讯作者25篇，第二作者3篇，篇均影响因子4.2，他引超过500次（Web of Science）。Chemical Reviews、Journal of the American Chemical Society、Biomaterials等15种SCI期刊21次邀请论文评审。
　　（28）Sun K, Wu S, Wang Y, Wan X, Thompson HJ, Zhang J*. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem. Toxicol. 52:36–41, 2013.
　　（27）Wang Y, Lu H, Wang D, Li S, Sun K, Wan X, Taylor EW, Zhang J*. Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase. Toxicol. Appl. Pharmacol. 265:342-350, 2012.
　　（26）Wang D, Taylor EW, Wang Y, Wan X, Zhang J*. Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. Int. J. Nanomedicine 7:1711–1721, 2012.
　　（25）Li J, Sun K, Ni L, Wang X, Wang D, Zhang J*. Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity. Toxicol. Appl. Pharmacol. 258:376-383, 2012.
　　（24）Zhang J*, Taylor EW, Wan X, Peng D*. Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. Int. J. Nanomedicine 7:815–825, 2012.
　　（23）Lu Y, Zhang J, Wan X, Long M, Li D, Lei P, Zhang Z. Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion. Food Chem. 125:277-280, 2011.
　　（22）Li S, Zhang J*, Li J, Chen D, Matteucci M, Curd J, Duan J. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol. Trace Elem. Res. 136:294-301, 2010.
　　（21）Wang X, Zhang J*, Xu T. Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level. Eur. J. Heart Failure 11:154-162, 2009.
　　（20）Zhang J*, Wang X, Xu T. Elemental selenium at nano size(Nano-Se)as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol. Sci. 101:22-31, 2008.
　　（19）Zhang J*,Peng D, Lu H, Liu Q. Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite. Toxicol. Appl. Pharmacol. 226:251-259, 2008.
　　（18）Zhang J*, Wang X, Lu H. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127-136, 2008.
　　（17）Wang X, Zhang J*, Xu T. Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy. Eur. J. Pharmacol. 579:66-73, 2008.
　　（16）Zhang J*, Wang H, Peng D, Taylor EW. Further insight into the impact of sodium selenite on selenoenzymes: High-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol. Lett. 176:223-229, 2008.
　　（15）Zhang J*, Lu H, Wang X. Sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2 and three kinds of leukemia cells. Biol. Trace Elem. Res. 125:13-21, 2008.
　　（14）Li H, Zhang J, Wang T, Luo W, Zhou Q, Jiang G. Elemental selenium particles at nano size(Nano-Se)are more toxic to Medaka(Oryzias latipes)as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite. Aquat. Toxicol. 89:251-256, 2008.
　　（13）Wang H, Zhang J*, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic. Biol. Med. 42:1524-1533, 2007.
　　（12）Zhang J*, Lu H. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity. Free Radic. Biol. Med. 43:1574-1583, 2007.
　　（11）Wang X, Zhang J*, Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol. Appl. Pharmacol. 218:88-95, 2007.
　　（10）Zhang J*, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol. Appl. Pharmacol. 224:81-88, 2007.
　　（9）Peng D, Zhang J*, Liu Q, Taylor EW. Size effect of elemental selenium nanoparticles(Nano-Se)at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J. Inorg. Biochem. 101:1457-1463, 2007.
　　（8）Peng D, Zhang J*, Liu Q. Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo. Biol. Trace Elem. Res. 117:77-88, 2007.
　　（7）Zhang J*, Ma K, Wang H. Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase. Chem Biol. Interact. 162:24-30, 2006.
　　（6）Zhang J*, Wang H, Yan X, Zhang L. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76:1099-1109, 2005.
　　（5）Zhang J*, Wang H, BaoY, Zhang L. Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci. 75:237-244, 2004.
　　（4）Huang B#, Zhang J#, Hou J, Chen C. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic. Biol. Med. 35:805-813, 2003.(# contributed equally)
　　（3）Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24:497-503, 2003.
　　（2）Gao X, Zhang J, Zhang L. Hollow sphere selenium nanoparticles: their in-vitro anti hydroxyl radical effect. Adv. Mater. 14:290-293, 2002.
　　（1）Zhang J, Gao X, Zhang L, Bao Y. Biological effects of a nano red elemental selenium. Biofactors 15:27-38, 2001.

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