姓名
韩新亚
性别
男
最高学位
博士

职称/职务
副教授，硕士生导师，系党支部书记

研究方向
药物分子设计
（定向靶标的新型抑制剂先导结构发现及其调控机制）

邮箱
xinyahan@ahut.edu.cn; xinyah@126.com

学习工作经历
2016.6-至今：安徽工业大学，化学与化工学院，讲师，硕士生导师
2010.9-2016.6：华中师范大学，化学学院，有机化学专业，理学博士
2006.9-2010.6：青岛农业大学，化学与药学院，制药工程专业，工学学士



主要科研项目及成果
近期主持的部分科研项目：
1中国--匈牙利科技合作委员会例会交流项目，2018-II-2，2020.1-2021.12，10万，主持
2 科技部发展中国家****科学家来华工作计划，越南-18-001，2019.1-2019.12，15万，负责人
3山东大学微生物技术国家重点实验室开放课题，M2017-11，10万，2017.10-2019.9，主持
4安徽工业大学校青年基金项目，QZ201609，0.8万，2017.1-2018.12，主持
5安徽工业大学人才引进科研启动经费，10万，在研，主持
近期发表的部分论文:
1 Xinya Han, Yunyuan Huang, Lin Wei, Haifeng Chen, Yanrong Guo, Zilong Tang, Wei Hu, Qinfei Xia, Qi Wang, Jufen Yan*, Yanliang Ren*, Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase, Bioorg. Med. Chem. 2020, 28: 115624.
2 Qi Sun^#, Yuan Qiu^#, Jun Chen, Fengshou Wu, Xiaogang Luo, Yanrong Guo, Xinya Han*, Dawei Wang*, A colorimetric and fluorescence turn-on probe for the detection of palladium in aqueous solution and its application in vitro and in vivo, Spectrochim. Acta Part A 2020, 239, 118547.
3 Ling Jin, Li Zhang, Lei Yang, Xingrong Wua, Cheng Zhang, Kang Wei, Lifang He, Xinya Han*, Hongbin Qiao*, Abdullah M. Asiri, Khalid A. Alamry, and Kui Zhang*, Orange-Red, Green, and Blue Fluorescence Carbon Dots for White Light Emitting Diodes, J. Mater. Sci. Technol. 2020, 50, 184-191.
4 Jun Tang, Yali Cao, Fei Ruan, Fengfeng Li, Yangxin Jin, Minh Ngoc Ha, Xinya Han*, and Qingping Ke*, New Approach for Controllable Synthesis of N-MnOx Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis, Ind. Eng. Chem. Res. 2020, 59, 9408-9413.
5 Guanqing Yang^#, Zhengjie Liu^#, Ruilong Zhang*, Xiaohe Tian, Juan Chen, Guangmei Han, Bianhua Liu, Xinya Han, Yao Fu, Zhangjun Hu, and Zhongping Zhang*, A Multi-responsive Fluorescent Probe Reveals Mitochondrial Nucleoprotein Dynamics with Reactive Oxygen Species Regulation through Super-resolution Imaging, Angew. Chem. Int. Ed. 2020, 59, 2-9.
6 Zilong Song, Yun Zhu, Jingrui Liu Shuke Guo,Yucheng Gu, Xinya Han*, Hongqiang Dong, Qi Sun, Weihua Zhang*, Mingzhi Zhang*, Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety, Mol. Divers. 2020, https://doi.org/10.1007/s11030-020-10048-8
7 Yunyuan Huang^#, Lin Wei^#, Xinya Han^#, Haifeng Chen^#, Yanliang Ren*, Yanhong Xu, Rongrong Song, Li Rao, Chen Su, Chao Peng, Lingling Feng, Jian Wan*, Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects, Eur. J. Med. Chem. 2019, 184(15), 111749-11762.
8 Qinghe Gao*^,#, Xinya Han^#, Peiyuan Tong, Zhiang Zhang, Haotian Shen, YanrongGuo, Suping Bai, Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N BondCleavage of Triethylamine: Difunctional Ammonium Iodide Enablingthe Regioselective Synthesis of 4-Arylpyrimido[1,2-b]indazoles, Org. Lett. 2019, 21 (15), 6074-6078.
9 Jufen Yan, Jianhua Zhu*, Mingfang Cui, Jing Zhang, Fang Ma, Yiping Su, and Xinya Han*, Multifunctional Mineral Hydrogels: Potential in ArtificiallyIntelligent Skins and Drug Delivery, ACS Omega 2019, 4, 19145-19152.
10 Xinya Han^#, Xiuyun Zhu^#, Zongqin Hong^#, Lin We, Yanliang Ren*, Fen Wan, Shuaihua Zhu, Hao Peng, Li Guo, Li Rao, Lingling Feng, and Jian Wan*, Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans, J. Chem. Inf. Model. 2017, 57 (6), 1426-1438.
11 Xinya Han^#, Yunyuan Huang^#, Rui Zhang^#, Shan Xiao, Shuaihua Zhu, Nian Qin, Zongqin Hong, Lin Wei, Jiangtao Feng, Yanliang Ren, Lingling Feng*, and Jian Wan*, New Insight into the Binding Modes of TNP-AMP to the Human Liver Fructose-1,6-bisphosphatase, Spectrochim. Acta Part A 2016, 165 (5), 155-160.
12 Xinya Han^#, Xiuyun Zhu^#, Shuaihua Zhu^#, Lin Wei, Li Rao, Zongqin Hong, Li Guo, Haifeng Chen, Bo Chi, Yan Liu, Lingling Feng, Yanliang Ren*, and Jian Wan*, A Rational Design, Synthesis, Biological Evaluation and Structure?Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase, J. Chem. Inf. Model. 2016, 56 (1), 73-81.
13 Haifeng Chen^#, Xinya Han^#, Nian Qin^#, Lin Wei, Yue Yang, Li Rao, Bo Chi, Lingling Feng, Yanliang Ren,* and Jian Wan* Synthesis and Biological Evaluation of β-Nitrostyrene Derivatives as Antifungal Agents Against Magnaporthegrisea, Bioorg. Med. Chem. 2016, 24 (6), 1225-1230.
14 Ding Li^#, Xinya Han^#, QidongTu^#, Lingling Feng, Di Wu, Yao Sun, Haifeng Chen, Yongjian Li, Yanliang Ren,* and Jian Wan*,Structure-Based Design and Synthesis of Novel Dual-TargetInhibitors Against Cyanobacterial Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6- Bisphosphatase, J. Agric. Food Chem. 2013, 61 (31), 7453-7461.